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U.S. Department of Health and Human Services

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Title:  A pharmacokinetic study of flumequine in sea bass, Dicentrarchus labrax (L.), after a single intravascular injection.
 
Authors:  Rigos G, Tyrpenou A, Nengas I, Alexis M
 
Drug:  Flumequine
 
Fish species:  Seabass, European
 
Date:  2002
 
t1/2-hr:  11
 
Sample:  blood, plasma
 
Ave Weight (gm):  120
 
Ave Water temp (°C):  18
 
Water:  Saltwater
 
Dosage:  10 mg/kg sd
 
Route:  IV
 
Comments:  Saltwater 38 ppt. t1/2=10.71 h beta, 1.05 alpha. AUC=53.5. Plasm conc ug/ml 0.5h=11.6, 1h=9.8, 2h=4.7, 4h=2.9, 7h=1.2,24h=0.3, 48h=0.2, 64h=0.018, 150h=nd.
 
Cl:  0.156 L/kg/h
 
Vc:  0.626 L/kg
 
Vd:  1.51 L/kg
 
Citation:  J. Fish Diseases 25:101-105
 
Link:  http://dx.doi.org/10.1046/j.1365-2761.2002.00340.x  Opens a new window
 
Genus Species:  Dicentrarchus labrax
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  10.71 h beta, 1.05 alpha
 
Wt gm-detail:  120 g
 
Water temp (°C)-detail:  18+/-0.5 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Rigos G, Tyrpenou A, Nengas I, Alexis M
 
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