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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of emamectin benzoate administered to Atlantic salmon, Salmo salar L., by intra-peritoneal injection
 
Authors:  Glover KA, Samuelsen OB, Skilbrei OT, Boxaspen K, Lunestad BT
 
Drug:  Emamectin benzoate
 
Fish species:  Salmon, Atlantic
 
Date:  2010
 
t1/2-hr:  11
 
Sample:  muscle
 
Ave Weight (gm):  37
 
Ave Water temp (°C):  12.7
 
Water:  Freshwater
 
Dosage:  0.438 mg/kg (mean) SD
 
Route:  IP
 
Comments:  Mean concentraion of emamectin benzoate: 7 days=449ug/kg, 21d=158, 42d=28, 63d=10. This study suggest that the concentration of emamectin benzoate in muscle. following a single IP injection, is higher than when the drug is administered in a similar dose via feed. Elimination half lives are similar to previous results obtained with oral administration and appear to be independent of water salinity.
 
Citation:  J. of Fish Diseases 33: 183-186
 
Link:  http://www3.interscience.wiley.com/journal/122581013/abstract  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antiparasitic-Avermectin
 
t1/2-detail:  11.1
 
Wt gm-detail:  36.5 (SD6.3)
 
Water temp (°C)-detail:  12.7 (11.2-14.2)
 
Dosage-detail:  438 ug/kg mean. Range =293-744
 
Method:  HPLC/MS
 
Authors-red:  Glover K, Samuelsen O, Skilbrei O, Boxaspen K, Lunestad B
 
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