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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of emamectin benzoate administered to Atlantic salmon, Salmo salar L., by intra-peritoneal injection
 
Authors:  Glover KA, Samuelsen OB, Skilbrei OT, Boxaspen K, Lunestad BT
 
Drug:  Emamectin benzoate
 
Fish species:  Salmon, Atlantic
 
Date:  2010
 
Sample:  skin
 
Ave Weight (gm):  50
 
Ave Water temp (°C):  12.7
 
Water:  Freshwater
 
Dosage:  0.2 mg/kg SD
 
Route:  IP
 
Comments:  pilot study. Mean concentration of emamectin benzoate in muscle 14 days post-injection = 159.9. Individual injection volumes ranged from 0.04-0.18 mL per fish to achieve identical dosages between fish.For all dosages, skin concentration was considerably higher than muscle. Also, a clear relationship between dose and resultant concentration was observed.
 
Citation:  J. of Fish Diseases 33: 183-186
 
Link:  http://www3.interscience.wiley.com/journal/122581013/abstract  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antiparasitic-Avermectin
 
Wt gm-detail:  49.7 (SD16.3)
 
Water temp (°C)-detail:  12.7 (11.2-14.2)
 
Dosage-detail:  100 ug/mL=200ug/kg
 
Method:  HPLC/MS
 
Authors-red:  Glover K, Samuelsen O, Skilbrei O, Boxaspen K, Lunestad B
 
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