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Title:  Evaluation of the dorsal aorta cannulation technique for pharmacokinetic studies in Atlantic salmon, (Salmo salar) in sea water.
 
Authors:  Sohlberg S, Martinsen B, Horsberg TE, Soli NE (1996)
 
Drug:  Flumequine
 
Fish species:  Salmon, Atlantic
 
Date:  1996
 
t1/2-hr:  67
 
Sample:  blood
 
Ave Weight (gm):  833
 
Ave Water temp (°C):  11
 
Water:  Saltwater
 
Dosage:  25 mg/kg sd
 
Route:  IV
 
Comments:  Vd= cannnulated, group 1 = 3.1 (0.5), group 2 (crossover)= 3.5 (0.9)(L/kg); crossover study refers to one of the groups that was given flumequine PO and IV, t 1/2 cannulated, group 1 = 67(10), group 2 (crossover study)= 60 (19)h
 
Cl:  cannulated, group1 = 0.068, group 2 =0.075 L/kg/h
 
Vd:  cannnulated, group 1 = 3.1, group 2= 3.5 L/kg
 
Citation:  J. Veterinary Pharmacology and Therapeutics 19:460-465
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8971675&dopt=Abstract  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  cannulated, group 1 = 67(10)group 2 (crossover study)= 60 (19)h
 
Wt gm-detail:  833 +/- 181 g
 
Water temp (°C)-detail:  11.1 +/- 0.2C
 
Dosage-detail:  25 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Sohlberg S, Martinsen B, Horsberg TE, Soli NE (1996)
 
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