Quick Links: Skip to main page content
Skip to Search
Skip to Topics Menu
Skip to Common Links
U.S. Food & Drug Administration
Follow FDA
En Español
Search FDA
Home
Food
Drugs
Medical Devices
Radiation-Emitting Products
Vaccines, Blood & Biologics
Animal & Veterinary
Cosmetics
Tobacco Products
PhishPharm - Detail
FDA Home
PhishPharm
Detail
-
Please note:
JavaScript must be enabled for this application to work properly.
Check your settings
if you are unsure if your JavaScript is enabled.
Title:
Pharmokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus).
Authors:
Park BK, Lim JH, Kim MS, Yun HI
Drug:
Florfenicol
Fish species:
Catfish, amur
Date:
2006
t1/2-hr:
11
Sample:
blood, plasma
Ave Weight (gm):
280
Ave Water temp (°C):
24
Water:
Freshwater
Dosage:
20 mg/kg sd
Route:
IV
Comments:
Plasma florfenicol and florfenicol amine concentration were analyzed for eash fish. Fish were deeply anesthetized with MS-222. Florfenicol: AUC=269.64 mg*h/L, MRT=12.69 h. Florfenicol amine: T1/2=14h, AUC=70.00 mg*h/L, Tmax=0.50 h, Cmax=3.91 mg/L, MRT=17.65 h, Metabolic ratio=25.96%.
Cl:
0.07 L/kg/h
Vd:
1.09 L/kg
Metabolites:
Florfenicol amine
Citation:
J. Veterinary Pharmacology and Therapeutics 29:37-40
Link:
http://dx.doi.org/10.1111/j.1365-2885.2006.00709.x
Genus Species:
Silurus asotus
Drug Class:
Antiobiotic-phenicol
t1/2-detail:
Metabolite:14.03+/- 1.82 h. Florfenicol:11.12+/- 1.03 h
Wt gm-detail:
280.4+/-20.8 g
Water temp (°C)-detail:
23.5+/-1.7C
Dosage-detail:
20 mg/kg sd
Method:
LC/MS
Authors-red:
Park BK, Lim JH, Kim MS, Yun HI
-
-