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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Pharmacokinetics of oxytetracycline in the American horseshoe crab,Limulus polyphemus
 
Authors:  Nolan MW, Smith SA, Jones D
 
Drug:  Oxytetracycline
 
Fish species:  Crab, Atlantic horseshoe
 
Date:  2007
 
t1/2-hr:  128
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  1790
 
Ave Water temp (°C):  21
 
Water:  Saltwater
 
Dosage:  25 mg/kg sd
 
Route:  ICS
 
Comments:  AUC 9524.6 ug/h/ml, MRT 443.65 h, Cmax 55.9 ug/ml, Cave 27.39 ug/ml salinity 27-29 ppt. Hemolymph levels rose again at 10-20 d post dose, possible enterohepatic recirculation. Intra-cardiac-sinus.
 
Cl:  0.0026
 
Vd:  1.164
 
Citation:  J. Veterinary Pharmacology and Therapeutics 30:451-455
 
Link:  http://www.ncbi.nlm.nih.gov/pubmed/17803738?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Opens a new window
 
Genus Species:  Limulus polyphemus
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  128.3 h
 
Wt gm-detail:  male 889+/-90 g, female 2700+/-30g
 
Water temp (°C)-detail:  19-22 C
 
Dosage-detail:  25 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Nolan MW, Smith SA, Jones D
 
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