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Title:
Determination and kinetics of enrofloxacin and ciprofloxacin in tra catfish (Pangasianodon hypophthalmus) and giant freshwater prawn (Macrobrachium rosenbergii) using a liquid chromatography/mass spectrometry method.
Authors:
Danyi S, Widart J, Douny C, Dang PK, Baiwir D, Wang N, Tu HT, Tung VT, Phuong NT, Krestemont P, Scippo ML
Drug:
Enrofloxacin
Fish species:
Catfish, striped (tra)
Date:
2010
Sample:
muscle+skin
Ave Weight (gm):
13
Ave Water temp (°C):
31
Water:
Freshwater
Dosage:
20 mg/kg 7d
Route:
PO
Comments:
Fish were euthanized on ice. Fish were distributed in three densities. For a density of 40 fish/m3:enrofloxacin (EF) concentration 0d post-dose=1200 ug/kg, 1d post-dose=396 ug/kg, 3d post-dose=200 ug/kg, 7d post-dose=98 ug/kg; ciprofloxacin (CF) concentration 0d post-dose=50 ug/kg, 1d post-dose=22 ug/kg, 3d post-dose=14 ug/kg, 7d post-dose=13 ug/kg.Mean detected levels of CF was much lower than EF, indicating only a small portion of EF is metabolized in CF.
Metabolites:
ciprofloxacin
Citation:
J. Veterinary Pharmacology and Therapeutics 34:142-152
Link:
http://dx.doi.org/10.1111/j.1365-2885.2010.01204.x
Genus Species:
Pangasianodon hypophthalmus
Drug Class:
Antiobiotic-quinolone
Wt gm-detail:
12.9+/-1.4 g
Water temp (°C)-detail:
29-32 C
Dosage-detail:
20 mg/kg 7d
Method:
LC/MS
Authors-red:
Danyi S, Widart J, Douny C, Dang PK, Baiwir D, Wang N, Tu HT, Tung VT, Phuong NT, Krestemont P, Scippo ML
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