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Title:  Determination and kinetics of enrofloxacin and ciprofloxacin in tra catfish (Pangasianodon hypophthalmus) and giant freshwater prawn (Macrobrachium rosenbergii) using a liquid chromatography/mass spectrometry method.
 
Authors:  Danyi S, Widart J, Douny C, Dang PK, Baiwir D, Wang N, Tu HT, Tung VT, Phuong NT, Krestemont P, Scippo ML
 
Drug:  Enrofloxacin
 
Fish species:  Catfish, striped (tra)
 
Date:  2010
 
Sample:  muscle+skin
 
Ave Weight (gm):  13
 
Ave Water temp (°C):  31
 
Water:  Freshwater
 
Dosage:  20 mg/kg 7d
 
Route:  PO
 
Comments:  Fish were euthanized on ice. Fish were distributed in three densities. For a density of 80 fish/ m3:EF concentration 0d post-dose-dose =5095 ug/kg, 1d post-dose=753 ug/kg, 3d post-dose=387 ug/kg, 7d post-dose=131 ug/kg;CF concentration 0d post-dose=155 ug/kg, 1d post-dose=35 ug/kg, 3d post-dose=20 ug/kg, 7d post-dose=15 ug/kg. Mean detected levels of CF was much lower than EF, indicating only a small portion of EF is metabolized in CF.
 
Metabolites:  ciprofloxacin
 
Citation:  J. Veterinary Pharmacology and Therapeutics 34:142-152
 
Link:  http://dx.doi.org/10.1111/j.1365-2885.2010.01204.x  Opens a new window
 
Genus Species:  Pangasianodon hypophthalmus
 
Drug Class:  Antiobiotic-quinolone
 
Wt gm-detail:  12.9+/-1.4 g
 
Water temp (°C)-detail:  29-32 C
 
Dosage-detail:  20 mg/kg 7d
 
Method:  LC/MS
 
Authors-red:  Danyi S, Widart J, Douny C, Dang PK, Baiwir D, Wang N, Tu HT, Tung VT, Phuong NT, Krestemont P, Scippo ML
 
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