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Title:
Effect of temperature on the pharmacokinetics of benzocaine in rainbow trout (Oncorhynchus mykiss) after bath exposures.
Authors:
Stehly GR, Meinertz JR, Gingerich WH (1998)
Drug:
Benzocaine
Fish species:
Trout, rainbow
Date:
1998
t1/2-hr:
1
Sample:
blood, plasma
Ave Weight (gm):
1099
Ave Water temp (°C):
6
Water:
Freshwater
Dosage:
1 mg/l 4 h
Route:
BATH
Comments:
Uptake clearance and metabolic clearance increased with increased acclimation temperatures. The elimination half-life of benzocaine in plasma did not differ significantly with temperature. Vd was normalized, calculated from total volume (bath+fish). Concentration at 240 min bath = 1538 ng/ml, 2.5 min post exposure = 242 ng/ml.
Cl:
0.91 L/kg/h
Vd:
2.369 g/kg*
Citation:
J. Veterinary Pharmacology and Therapeutics. 21:121-127
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9597649
Genus Species:
Oncorhynchus mykiss
Drug Class:
Anesthetic-Benzocaine
t1/2-detail:
1.01+/-0.505 h
Wt gm-detail:
1099 g
Water temp (°C)-detail:
6 C
Dosage-detail:
1 mg/l for 4 h
Method:
HPLC/RP
Authors-red:
Stehly GR, Meinertz JR, Gingerich WH (1998)
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