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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of enrofloxacin in koi carp (Cyprinus carpio) after various routes of administration.
 
Authors:  Udomkusonsri P, Arthitvong S, Klangkaew N, Kusucharit N
 
Drug:  Enrofloxacin
 
Fish species:  Carp, common (koi)
 
Date:  2007
 
t1/2-hr:  17
 
Sample:  blood, plasma
 
Ave Weight (gm):  78
 
Ave Water temp (°C):  28
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  PO
 
Comments:  Fish were sedated with clove oil (10mg/L). Cmax = 14mg/L, Tmax = 0.25h, AUC = 156mg/h/L, MRT = 23.enrofloxacin concentration in plasma at time points (mg/L): 0h=0.00, 0.25 h=14, 0.5h=13, 1h=11, 2h=4, 8h=6, 24h=1, 48h=0.6, 72h=0.6, 96=0.2. The authors claim that plasma drug concentrations were above MIC for most fish bacterial pathogens, making this an effective dose.
 
Cl:  0.064
 
Vd:  1.5 L/kg
 
Citation:  Kasetsart J. (Natural Science) 41:62-68
 
Link:  http://www.thaiscience.info/journals/Article/Pharmacokinetics%20of%20enrofloxacin%20in%20koi%20carp%20(cyprinus%20carpio)%20after%20various%20routes%20of%20administration.pdf  Opens a new window
 
Genus Species:  Cyprinus carpio
 
Drug Class:  Antibiotic - Quinolone
 
t1/2-detail:  16.6
 
Wt gm-detail:  78.3+/-5.3
 
Water temp (°C)-detail:  27-28
 
Dosage-detail:  10 mg/kg sd
 
Method:  Micro
 
Authors-red:  Udomkusonsri P, Arthitvong S, Klangkaew N, Kusucharit N
 
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