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Title:  Pharmacokinetics of enrofloxacin in koi carp (Cyprinus carpio) after various routes of administration.
 
Authors:  Udomkusonsri P, Arthitvong S, Klangkaew N, Kusucharit N
 
Drug:  Enrofloxacin
 
Fish species:  Carp, common (koi)
 
Date:  2007
 
t1/2-hr:  42
 
Sample:  blood, plasma
 
Ave Weight (gm):  78
 
Ave Water temp (°C):  28
 
Water:  Freshwater
 
Dosage:  5 mg/L 5 hrs
 
Route:  BATH
 
Comments:  Fish were sedated with clove oil (10mg/L). Cmax =1.0, Tmax = 0.25, AUC = 29, MRT = 75. Mean enrofloxacin concentration in plasma at time points (mg/L): 0h*=0.00, 0.25h=0.9, 0.5h=0.8, 1h=0.8, 2h=0.6, 8h=0.2, 24h=0.2, 48h=0.2, 72h=0.2, 96=0.2. *time 0h was taken before bath treatment. The authors claim that plasma drug concentrations were above MIC for most fish bacterial pathogens, making this an effective dose.
 
Cl:  0.172
 
Vd:  10.4 L/kg
 
Citation:  Kasetsart J. (Natural Science) 41:62-68
 
Link:  http://www.thaiscience.info/journals/Article/Pharmacokinetics%20of%20enrofloxacin%20in%20koi%20carp%20(cyprinus%20carpio)%20after%20various%20routes%20of%20administration.pdf  Opens a new window
 
Genus Species:  Cyprinus carpio
 
Drug Class:  Antibiotic - Quinolone
 
t1/2-detail:  42.1
 
Wt gm-detail:  78.3+/-5.3
 
Water temp (°C)-detail:  27-28
 
Dosage-detail:  5 mg/L 5 hrs
 
Method:  Micro
 
Authors-red:  Udomkusonsri P, Arthitvong S, Klangkaew N, Kusucharit N
 
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