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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Pharmacokinetics of proflavine in rainbow trout.
 
Authors:  Yu Z, Abbas A, Vick A, Doddapaneni S, Hayton WL
 
Drug:  Proflavine
 
Fish species:  Trout, rainbow
 
Date:  1994
 
t1/2-hr:  28
 
Sample:  blood, plasma
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  0.7 mg/kg sd
 
Route:  IVC
 
Comments:  Total body clearnace very large considering cardiac output, indicating possible excretion via gills. Proflavine (14)C.
 
Cl:  1.4 L/kg/h
 
Vd:  35 L/kg
 
Metabolites:  Unidentified metabolite
 
Citation:  Pharmaceutical Research 11:10:S-384
 
Link:  none  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Dye
 
t1/2-detail:  28 h
 
Wt gm-detail:  Not specified
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  0.7 mg/kg sd
 
Method:  HPLC/RP, HPLC-Rad
 
Authors-red:  Yu Z, Abbas A, Vick A, Doddapaneni S, Hayton WL
 
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