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U.S. Department of Health and Human Services

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Title:  The disposition of ivermectin in Atlantic salmon (Salmo salar).
 
Authors:  Hoy T, Horsberg TE, Nafstad I
 
Drug:  Ivermectin
 
Fish species:  Salmon, Atlantic
 
Date:  1990
 
Sample:  blood
 
Ave Weight (gm):  68
 
Ave Water temp (°C):  7
 
Water:  Saltwater
 
Dosage:  2.96 MBq sd (2220 MBq/mg -0.2 ml dose)
 
Route:  PO
 
Comments:  28 d after dose, 19% of the dose was still present in blood, muscle, liver, kidney. The difference in total amount of radioactivity in blood, muscle, liver, and kidney at day 4 after treatment compared with day 28 was only 35%, the drug accumulates in fatty tissues. 50% of drug excreted via the bile is parent compound. Ivermectin (22,23 di-3H-avermectin, B1a) .
 
Metabolites:  Unidentified major and other polar metabolites
 
Citation:  Pharmacology and Toxicology 67:307-312
 
Dep-time:  > 28 d
 
Link:  none  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antiparasitic-Avermectin
 
Wt gm-detail:  68 +/- 11 g
 
Water temp (°C)-detail:  7.1 +/- .5 C
 
Dosage-detail:  2.96 MBq sd (2220 MBq/mg -0.2 ml dose)
 
Method:  Rad
 
Authors-red:  Hoy T, Horsberg TE, Nafstad I
 
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