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Title:  In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity.
 
Authors:  Perkins EJ Jr, Schlenk D
 
Drug:  Aldicarb
 
Fish species:  Catfish, channel
 
Date:  2000
 
t1/2-hr:  2
 
Sample:  blood, plasma
 
Ave Weight (gm):  750
 
Ave Water temp (°C):  22
 
Water:  Freshwater
 
Dosage:  0.32 mg sd
 
Route:  IVC
 
Comments:  (14C)-Aldecarb. Cannulated fish. Conc ng/ml 1h=80, 3h=70, 6h=20, 12h=1. Sulfoxide ng/ml 0.04h=12, 0.06h=30, 0.17=45, 0.5=45, 1h=55, 3h=65, 6h=75, 12h=65, 24h=65, 36h=60, 48h=25 ng/ml. AUC=490.8 Trout metabolize 3X more to the sulfoxide by 3 hrs than do catfish.
 
Cl:  0.65 L/h
 
Vd:  1.9 L/kg
 
Metabolites:  Sulfoxide, Sulfone
 
Citation:  Toxicological Sciences 53:308-315
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10696779  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Carbamate-Pesticide
 
t1/2-detail:  1.9 h
 
Wt gm-detail:  700-800
 
Water temp (°C)-detail:  18-25 C
 
Dosage-detail:  0.32 mg sd
 
Method:  HPLC-Rad
 
Authors-red:  Perkins EJ Jr, Schlenk D
 
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