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Title:
Toxicokinetics of parathion and paraoxon in rainbow trout after intravascular administration and water exposure.
Authors:
Abbas R, Schultz IR, Doddapaneni S, Hayton WL
Drug:
Paraoxon
Fish species:
Trout, rainbow
Date:
1996
t1/2-hr:
1
Sample:
blood, plasma
Ave Weight (gm):
345
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
75 ng/ml up to 120 hrs
Route:
BATH
Comments:
Concentrations ng/ml during exposure- 0.25h=70.3, 0.5h=85.6, 1h=88.7, 1.5h=92.4, 2h=101.7, 4h=104.3, 6h=103.8, 12h=102.6, 24h=101.1, 48h=99.2, 72h=98.9 (rapid uptake and then plateau).
Cl:
2.78 L/kg/h
Vd:
1.04 L/kg
Citation:
Toxicology and Applied Pharmacology 136:194-199
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8560474&dopt=Abstract
Genus Species:
Oncorhynchus mykiss
Drug Class:
Organic-Phosphorus-Pesticide
t1/2-detail:
0.535 h
Wt gm-detail:
140-550 g
Water temp (°C)-detail:
12 C
Dosage-detail:
75 ng/ml up to 120 hrs
Method:
GC
Authors-red:
Abbas R, Schultz IR, Doddapaneni S, Hayton WL
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