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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Pharmacodynamics of methyl mercury in the rainbow trout (Salmo gairdneri): Tissue uptake, distribution and excretion.
 
Authors:  Giblin FJ, Massaro EJ
 
Drug:  Mercury-(Methyl Mercury)
 
Fish species:  Trout, rainbow
 
Date:  1973
 
Sample:  muscle
 
Ave Weight (gm):  270
 
Ave Water temp (°C):  7
 
Water:  Freshwater
 
Dosage:  0.5 mg/kg sd
 
Route:  PO
 
Comments:  Biological half-retention time is > 200 d; if the value of 0.05% of the dose is taken as the average daily excretion of methyl mercury, a not unreasonable value of 1000 d is calculated for its biological half-retention time, the excretion must occur in at least 2 stages. Peak at 34 d = 1.00 ng/gm, 56 d= 0.8, 92 d= 0.93, 100d = 0.9.
 
Citation:  Toxicology and Applied Pharmacology 24:81-91
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4686788&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Metal-Mercury-Methyl
 
t1/2-detail:  760 h
 
Wt gm-detail:  270g
 
Water temp (°C)-detail:  5~9 C
 
Dosage-detail:  0.5 mg/kg sd
 
Method:  Rad
 
Authors-red:  Giblin FJ, Massaro EJ
 
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