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U.S. Department of Health and Human Services

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Title:  A review of the pharmacokinetics and metabolism of sulfadimethoxine in the rainbow trout (Salmo gairdneri).
 
Authors:  Kleinow KM, Lech JJ
 
Drug:  Sulfadimethoxine
 
Fish species:  Trout, rainbow
 
Date:  1988
 
t1/2-hr:  17
 
Sample:  blood, plasma
 
Ave Weight (gm):  415
 
Ave Water temp (°C):  0
 
Water:  Freshwater
 
Dosage:  42 mg/kg sd
 
Route:  IVC
 
Comments:  Single dose = 16.9 h, multiple dose = 36.4 h, Vd= 500 ml/kg; Low magnitude, non-specific, non-saturable plasma protein binding. Residue at 4h=1.48, 12 hr= 54.18, 72 h= 9.23, 336 h= nd (ug/ml). Sulfadimethoxine-(35S).
 
Protein binding:  0.17
 
Vd:  0.50L/kg
 
Metabolites:  N-A-SDM, 2 polar metabolites
 
Citation:  Veterinary and Human Toxicology 30 (supp 1):26-30
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3212939&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  16.9 h
 
Wt gm-detail:  180-650 g
 
Water temp (°C)-detail:  Not Specified
 
Dosage-detail:  42 mg/kg sd
 
Method:  Rad
 
Authors-red:  Kleinow KM, Lech JJ
 
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