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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of sulphadimidine in carp (Cyprinus carpio L.) and rainbow trout (Salmo gairdneri Richardson) acclimated at two different temperature levels.
 
Authors:  Van Ginneken VJTh., Nouws JFM, Grondel JL, Driessens F, Degen M
 
Drug:  Sulfadimidine
 
Fish species:  Carp, common
 
Date:  1991
 
t1/2-hr:  28
 
Sample:  blood, plasma
 
Ave Weight (gm):  421
 
Ave Water temp (°C):  20
 
Water:  Freshwater
 
Dosage:  100 mg/kg sd
 
Route:  IV
 
Comments:  N4-SDM=5.62+/-0.77%, SCH2OH= 0.67+/-0.44%. T1/2 at 10 C = 50.3 vs 20 C= 25.6 h- approx 1 day difference due to temperature.
 
Cl:  0.02466 L/kg/h
 
Vd:  0.90+/-0.07 L/kg
 
Metabolites:  N4-A-sulfadimidine, SCH2OH
 
Citation:  Veterinary Quarterly 13:2:88-96
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1882494&dopt=Abstract  Opens a new window
 
Genus Species:  Cyprinus carpio
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  25.6+/-2.6h
 
Wt gm-detail:  421+/-44g
 
Water temp (°C)-detail:  20C
 
Dosage-detail:  100 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Van Ginneken VJTh., Nouws JFM, Grondel JL, Driessens F, Degen M
 
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