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U.S. Department of Health and Human Services

Cumulative Estimated Daily Intake (CEDI)

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Database updated November 2023

As part of the premarket notification process for food contact substances (FCSs), the Office of Food Additive Safety (OFAS) maintains a database of cumulative estimated daily intakes (CEDIs) for a large number of FCSs. This database is referred to as the CEDI database and is publicly available. FDA updates the CEDI database as additional information becomes available.

The CEDIs in the database were calculated using information currently available at the time and may be subject to revision on the basis of new information as it is made available and evaluated or existing information is re-evaluated by OFAS.

Information for FCS Notifiers

As the safety evaluation is the responsibility of the notifier, potential notifiers are encouraged to approach OFAS through a prenotification consultation to determine if their proposed use is supported by the available data. This is especially critical if the current CEDI may change substantially as a result of the intended use. Notifiers are also encouraged to contact OFAS with new information that may be used to calculate CEDIs and include such information in notifications. See Preparation of Food Contact Notifications and Food Additive Petitions for Food Contact Substances: Chemistry Recommendations. Concerning the database, OFAS notes the following:

  • The CEDI values listed in the database are primarily for FCSs that are regulated under 21 CFR 175-178 and/or authorized by a Food Contact Substance Notification. Information on constituents, such as monomers, and other impurities may not currently be available.
  • The listed CEDI values for polymeric FCSs in the database are predominately for exposure to the associated low molecular weight oligomers.
  • The CEDI values are expressed as both cumulative dietary concentration (CDC, parts-per-billion, ppb) and as cumulative estimated daily intake (CEDI, microgram/kilogram body weight/person/day, µg/kg bw/d).

 


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Records Found: 1257 Show All Page 1 of 26
CAS Reg. No.*
(or other ID*)
Substance*
(sorted A-Z)
CEDI*
(µg/kg bw/d)
CDC*
(ppb)
Calculation/update* Date 21 CFR*
78-63-7 (1,1,4,4-TETRAMETHYLTETRAMETHYLENE)BIS(TERT-BUTYL PEROXIDE)
0.01
0.2
Jun 17, 2010 177.1520
177.2600
68259-36-9 (2,4,4-TRIMETHYLPENT-2-YL)-N-PHENYL-1-NAPHTHYLAMINE
2.5
50
Jul 24, 2007
6891-44-7 (2-(METHACRYLOYLOXY)ETHYL)TRIMETHYLAMMONIUM METHYL SULFATE
0.02
0.4
Sep 6, 2000 173.10
178.3520
68784-12-3 (2-ALKENYL(C15-21))SUCCINIC ANHYDRIDE
2.6
52
Oct 23, 2015 176.170
26401-86-5 (N-OCTYL)TIN S,S',S''-TRIS(ISOOCTYLMERCAPTOACETATE)
0.385
7.7
Jul 22, 1985 178.2650
4118-16-5 1,1'-((6-PHENYL-1,3,5-TRIAZINE-2,4-DIYL)DIIMINO)BIS[9,10-ANTHRACENEDIONE]
0.025
0.5
Mar 21, 1985 178.3297
94-03-1 1,1'-OXYBIS(2-PROPANOL) DIBENZOATE
0.85
17
Jun 20, 2000
1163733-25-2 1,1,2,2-TETRAFLUORO-2-[(1,2,2-TRIFLUOROETHENYL)OXY]ETHANESULFONYL FLUORIDE, POLYMER WITH 1,1,2,2-TETRAFLUOROETHENE, HYDROLYZED
0.0000265
0.00053
Nov 13, 2017
1843-03-4 1,1,3-TRIS(5-TERT-BUTYL-4-HYDROXY-2-METHYLPHENYL)BUTANE
47
940
Nov 7, 1983 175.105
178.2010
75-37-6 1,1-DIFLUOROETHANE
0.55
11
Oct 15, 1992 178.3010
701.30
75-38-7 1,1-DIFLUOROETHENE
0.000035
0.0007
Feb 29, 2000 177.1350
177.1380
177.2510
177.2600
64253-30-1 1,11-(3,6,9-TRIOXAUNDECYL) BIS[3-(DODECYLTHIO)PROPIONATE]
0.6
12
Sep 26, 1996 178.2010
887192-39-4 1,12,23,34-TETRAAZACYCLOTETRATETRACONTANE-2,11,24,33-TETRONE
0.11
2.2
Aug 19, 2014
143423-02-3 1,12-DIAZACYCLODOCOSANE-2,11-DIONE
1.85
37
Aug 19, 2014
882073-43-0 1,2,3-TRIDEOXY-4,6:5,7-BIS-O-[(4-PROPYLPHENYL)METHYLENE]NONITOL
0.28
5.6
Jul 24, 2008
3319-31-1 1,2,4-BENZENETRICARBOXYLIC ACID, 1,2,4-TRIS(2-ETHYLHEXYL) ESTER
1.5
30
Apr 21, 2017
2855-27-8 1,2,4-TRIVINYLCYCLOHEXANE
0.0005
0.01
Aug 22, 2000
2634-33-5 1,2-BENZISOTHIAZOLIN-3-ONE
8.9
178
Jan 19, 2021 175.105
176.170
176.180
176.300
177.2600
32687-78-8 1,2-BIS(3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMOYL)HYDRAZINE
11.6
232
Dec 9, 2021 175.105
178.2010
3785-34-0 1,2-BIS(MONOBROMOACETOXY)ETHANE
0.02
0.4
Jun 19, 2000 176.300
16068-37-4 1,2-BIS(TRIETHOXYSILYL)ETHANE
0.016
0.32
Jan 14, 2008
491589-22-1 1,2-CYCLOHEXANEDICARBOXYLIC ACID, CALCIUM SALT
0.6
12
Mar 14, 2006
35691-65-7 1,2-DIBROMO-2,4-DICYANOBUTANE
1.9
38
Feb 2, 1996 175.105
175.300
175.320
176.170
176.210
176.300
113669-58-2 1,2-OCTANEDISULFONIC ACID
0.04
0.8
Jan 7, 1985 178.1010
106990-43-6 1,3,5-TRIAZINE-2,4,6-TRIAMINE, N,N'''-1,2-ETHANEDIYLBIS[N-[3-[[4,6-BIS[BUTYL(1,2,2,6,6-PENTAMETHYL-4-PIPERIDINYL)AMINO]-1,3,5-TRIAZIN-2-YL]AMINO]PROPYL]-N',N''-DIBUTYL-N',N''-BIS(1,2,2,6,6-PENTAMETHYL-4-PIPERIDINYL)-
2.25
45
Mar 30, 1999 178.2010
7779-27-3 1,3,5-TRIETHYLHEXAHYDRO-1,3,5-TRIAZINE
0.16
3.2
Dec 21, 2000 176.170
177.2600
26175-70-2 1,3,5-TRIS(3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMOYL)HEXAHYDRO-S-TRIAZINE
0.95
19
Dec 21, 2000 178.2010
40601-76-1 1,3,5-TRIS(4-TERT-BUTYL-3-HYDROXY-2,6-DIMETHYLBENZYL)-1,3,5-TRIAZINE-2,4,6-(1H,3H,5H)-TRIONE
67
1340
May 4, 1981 178.2010
281-86-7 1,3,6,8-TETRAAZATRICYCLO(6.2.1.1(3,6))DODECANE
0.5
10
Sep 6, 2000 176.300
108-45-2 1,3-BENZENEDIAMINE
0.5
10
Sep 9, 2002 177.2280
177.2550
42774-15-2 1,3-BENZENEDICARBOXAMINDE, N,N'-BIS(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)
10.15
203
Apr 17, 2018
27937-63-9 1,3-BENZENEDICARBOXYLIC ACID, 5-SULFO-, 1,3-DIMETHYL ESTER, SODIUM SALT (1:1), POLYMER WITH DIMETHYL 1,4-BENZENEDICARBOXYLATE AND 1,2-ETHANEDIOL
0.75
15
Oct 3, 2019
130758-99-5 1,3-BENZENEDICARBOXYLIC ACID, POLYMER WITH 1,4-BENZENEDICARBOXYLIC ACID AND 1,2-ETHANEDIOL BLOCK
7
140
Apr 29, 2002 177.1630
60088-52-0 1,3-BENZENEDICARBOXYLIC ACID, POLYMER WITH 1,4-BENZENEDICARBOXYLIC ACID, (1,1'-BIPHENYL)-4,4'-DIOL AND 4-HYDROXYBENZOIC ACID
1.25
25
Jul 1, 2016
62694-40-0 1,3-BENZENEDICARBOXYLIC ACID, POLYMER WITH AZACYCLOTRIDECAN-2-ONE, 1,4-BENZENEDICARBOXYLIC ACID AND 4,4'-METHYLENEBIS[2-METHYLCYCLOHEXANAMINE]
1.65
33
Nov 18, 2016
106-99-0 1,3-BUTADIENE
0.0009
0.018
Jul 25, 2014 175.105
176.170
176.180
177.1020
177.1030
177.1050
177.1480
177.1635
177.1810
177.2600
177.2800
178.3790
68441-13-4 1,3-BUTADIENE, 2-METHYL-, HOMOPOLYMER, OF CIS-1,4-CONFIGURATION, CYCLIZED
0.5
10
Jan 28, 2014
66070-58-4 1,3-BUTADIENE-STYRENE POLYMER, HYDROGENATED
0.05
1
Feb 27, 2007 177.1810
3971-28-6 1,3-CYCLOHEXANEDIMETHANOL
1.5
30
Mar 16, 2010
96-23-1 1,3-DICHLORO-2-PROPANOL
0.0009
0.018
Sep 29, 2004
6228-25-7 1,3-DIOXANE-5,5-DIMETHANOL
0.025
0.5
Feb 18, 2021
136504-96-6 1,3-PROPANEDIAMINE, N,N''-1,2-ETHANEDIYLBIS-, POLYMER WITH N-BUTYL-2,2,6,6-TETRAMETHYL-4-PIPERIDINAMINE AND 2,4,6-TRICHLORO-1,3,5-TRIAZINE
4.5
90
Apr 13, 1998 178.2010
1010121-89-7 1,3-PROPANEDIAMINE, N1-(9Z)-9-OCTADECEN-1-YL-, POLYMER WITH 2-(CHLOROMETHYL)OXIRANE
0.7
14
Oct 2, 2017
55636-09-4 1,3-PROPANEDIAMINIUM, 2-HYDROXY-N1,N1,N1,N3,N3,N3-HEXAMETHYL-, CHLORIDE
0.2167
4.334
Dec 17, 2008
6228-26-8 1,3-PROPANEDIOL, 2,2'-[METHYLENEBIS(OXYMETHYLENE)]BIS[2-(HYDROXYMETHYL)-
0.025
0.5
Feb 18, 2021
126-11-4 1,3-PROPANEDIOL, 2-(HYDROXYMETHYL)-2-NITRO
0.07
1.4
Mar 10, 2008
57609-64-0 1,3-PROPANEDIYL BIS(4-AMINOBENZOATE)
0.01
0.2
Jan 22, 1985 177.1680
82203-23-4 1,3:2,4-BIS-O-[(4-CHLOROPHENYL)METHYLENE]-D-GLUCITOL
1.2
24
Aug 7, 2008
657408-39-4 1,4-BENZENECARBOXYLIC ACID POLYMER WITH 1,10-DECANEDIAMINE AND 1,6-HEXANEDIAMINE
0.00014
0.0028
Feb 23, 2009
444992-04-5 1,4-BENZENEDIAMINE, N-(1,3-DIMETHYLBUTYL)-N'-PHENYL, REACTION PRODUCTS WITH ETHYLENE OXIDE MONO[[C12-RICH C10-13 BRANCHED ALKYL THIO]METHYL]DERIVATIVES
1.55
31
Oct 16, 2003

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*Definitions

  • CAS Reg. No. (or other ID): Chemical Abstract Service (CAS) Registry Number© for the substance or a numerical code (other ID) assigned by CFSAN to those substances that do not have a CAS Registry Number (977nnn-nn-n or 809777nnn-nn-n series).
  • Substance: A name of the additive or impurity as recognized by CFSAN.
  • Calculation/Update Date: The date on which the CEDI was calculated or re-evaluated.
  • CDC: Cumulative Dietary Concentration (CDC, parts-per-billion, ppb)
  • CEDI: Cumulative Estimated Daily Intake (micrograms/kilogram body weight/person/day, µg/kg bw/d)
  • 21 CFR: The Code of Federal Regulations, Title 21 is the preferred reference to determine the regulatory status of Indirect Food Additives. Substances whose names appear in 21 CFR, parts 175-178 are authorized for specified intended users and conditions of use as stated in the regulation. Note that substances may appear in more than one regulation, or several times in the same regulation. Note that if a substance is mentioned in 21 CFR parts 175-178 and thus, is listed above, any other citations for the same substance in other sections of 21 CFR dealing with food additives (parts 1-199 inclusive) may also be cited.
CAS Reg. No.*
(or other ID*)
Substance*
(sorted A-Z)
CEDI*
(µg/kg bw/d)
CDC*
(ppb)
Calculation/update* Date 21 CFR*
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