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Title:
Pharmacokinetics of morphine in fish: Winter flounder (Pseudopleuronectes americanus) and seawater-acclimated rainbow trout (Oncorhyncus mykiss).
Authors:
Newby NC, Mendonca PC, Gamperl K, Stevens ED
Drug:
Morphine
Fish species:
Flounder, winter
Date:
2006
t1/2-hr:
19
Sample:
blood, plasma
Ave Weight (gm):
433
Ave Water temp (°C):
10
Water:
Saltwater
Dosage:
17.4 mg/kg
Route:
IV
Comments:
A = 104 +/- 16.1 mg/L, ± = 1.27 +/- 0.09 per hour, B = 6.95 +/- 0.53 mg/L, ² = 0.0274 +/- 0.005 per hour, C0 = 111 +/- 15.7, AUCarea 340 +/- 12 mg h/L, AUMCarea 11,850 +/- 42 mg h2/L, MRTarea = 29.3 +/- 1.0 h. (Morphine Sulfate).
Vd:
1.42 +/- 0.137 L
Citation:
Comparative Biochemistry and Physiology 143C:275-283
Link:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16631414&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Genus Species:
Pseudopleuronectes americanus
Drug Class:
Analgesic-Morphine
t1/2-detail:
19.1 +/- 1.23
Wt gm-detail:
433 +/- 16 g
Water temp (°C)-detail:
4 C initally acclimated to 10 C
Dosage-detail:
7.5 mg/kg
Method:
ELISA
Authors-red:
Newby NC, Mendonca PC, Gamperl K, Stevens ED
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