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Title:
Pharmacokinetics, Bioavailability, and Protein Binding of Oxolinic Acid in Rainbow Trout
Authors:
Ueno R, Tatsuno T
Drug:
Oxolinic Acid
Fish species:
Trout, rainbow
Date:
2003
t1/2-hr:
69
Sample:
blood, serum
Ave Weight (gm):
126
Ave Water temp (°C):
15
Water:
Freshwater
Dosage:
20 mg/kg
Route:
IV
Comments:
Cmax=22.4ug/ml - decresed to 0.30 at day 22. Half life alpha=0.78. AUC=968. Total body clearance=11.0h. Bioavailibility=43.4%. Protein binding ranged from 21.2 at 0.5h to 47.1 at 288h. It reached its low of 21% at 3 hours and a high of 69.1% at
Protein binding:
21-69%
Cl:
413.2
Vc:
0.69
Vd:
1.88
Citation:
ITE Letters on Batteries, New Technology & Medicine, Vol. 4, no. 4
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
69.3h
Wt gm-detail:
126g
Water temp (°C)-detail:
15
Dosage-detail:
20mg/kg BW
Method:
HPLC
Authors-red:
Ueno R, Tatsuno T
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