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Title:
Pharmacokinetics of oxolinic acid in sea-bass, Dicentrarchus labrax (L., 1758), after a single rapid intravascular injection.
Authors:
Poher I, Blanc G, Loussouarn S
Drug:
Oxolinic acid
Fish species:
Seabass, European
Date:
1997
t1/2-hr:
87
Sample:
blood, plasma
Ave Weight (gm):
100
Ave Water temp (°C):
15
Water:
Saltwater
Dosage:
10 mg/kg sd
Route:
IV
Comments:
Distribution t1/2=0.69h; Vd= 2.55L/kg; Vc= 0.4L/kg Alpha t 1/2 = 0.69 h. Compared bioassay with HPLC - both similar.
Cl:
0.066L/kg/h
Vc:
0.4L/kg
Vd:
2.55L/kg
Citation:
J. Veterinary Pharmacology and Therapeutics 20:267-275
Link:
http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showAbstract&doi=10.1046/j.1365-2885.1997.00062.x&area=production&prevSearch=allfield%3A%28Poher%29
Genus Species:
Dicentrarchus labrax
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
86.6 h
Wt gm-detail:
100+/-10g
Water temp (°C)-detail:
15.2+/-0.2C
Dosage-detail:
10 mg/kg sd
Method:
HPLC, bioassay
Authors-red:
Poher I, Blanc G, Loussouarn S
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