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U.S. Department of Health and Human Services

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Title:  Plasma and tissue levels of trimethoprim in the Rainbow trout, Salmo gairdneri, after absorption from fresh and salt water.
Authors:  Bergsjo T, Sognen E
Drug:  Trimethoprim
Fish species:  Trout, rainbow
Date:  1980
Sample:  blood, plasma
Ave Weight (gm):  120
Ave Water temp (°C):  9
Water:  Saltwater
Dosage:  75 mg/l 5-48 hr sd
Route:  BATH
Comments:  Fish adapted to salt water for 7 d before study. Plasma concentration reached 1 ug/ml after10h. Higher absorption attributed to the addition of ingested medicated water to that absorbed in the gills. Saltwater adapted fish had highest levels of drug, followed by those not adapted, and least in freshwater dosed fish.
Citation:  Acta Veterinaria Scandinavia 21:18-25
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7386327  Opens a new window
Genus Species:  Oncorhynchus mykiss
Drug Class:  Antibiotic-Sulfa
t1/2-detail:  Not Specified
Wt gm-detail:  120 g
Water temp (°C)-detail:  9 C
Dosage-detail:  75 mg/l for 5-48 hr sd
Method:  Micro
Authors-red:  Bergsjo T, Sognen E