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U.S. Department of Health and Human Services

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Title:  Plasma and tissue levels of trimethoprim in the Rainbow trout, Salmo gairdneri, after absorption from fresh and salt water.
 
Authors:  Bergsjo T, Sognen E
 
Drug:  Trimethoprim
 
Fish species:  Trout, rainbow
 
Date:  1980
 
Sample:  blood, plasma
 
Ave Weight (gm):  120
 
Ave Water temp (°C):  9
 
Water:  Saltwater
 
Dosage:  75 mg/l 5-48 hr sd
 
Route:  BATH
 
Comments:  Fish adapted to salt water for 7 d before study. Plasma concentration reached 1 ug/ml after10h. Higher absorption attributed to the addition of ingested medicated water to that absorbed in the gills. Saltwater adapted fish had highest levels of drug, followed by those not adapted, and least in freshwater dosed fish.
 
Citation:  Acta Veterinaria Scandinavia 21:18-25
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7386327  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  Not Specified
 
Wt gm-detail:  120 g
 
Water temp (°C)-detail:  9 C
 
Dosage-detail:  75 mg/l for 5-48 hr sd
 
Method:  Micro
 
Authors-red:  Bergsjo T, Sognen E
 
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