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U.S. Department of Health and Human Services

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Title:  Bioavailability, metabolism, and renal excretion of benzoic acid in the channel catfish (Ictalurus punctatus).
 
Authors:  Plakas SM, James MO
 
Drug:  Benzoic acid
 
Fish species:  Catfish, channel
 
Date:  1989
 
t1/2-hr:  6
 
Sample:  blood, plasma
 
Ave Weight (gm):  500
 
Ave Water temp (°C):  28
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  Resiude 2 h= 22.7, 4 h=16.7, 24 h= 0.82, 48 h= 0.06 ug/ml. (14C) benzoic acid
 
Protein binding:  18+/-1%
 
Cl:  0.061 L/kg/h*
 
Vc:  0.295 L/kg
 
Vd:  0.369 L/kg
 
Citation:  American Society for Pharmacology and Experimental Therapeutics 18:5:552-556
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1981701  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Antifungal-Benzoic acid
 
t1/2-detail:  5.9 h
 
Wt gm-detail:  .51 +/- .16 kg
 
Water temp (°C)-detail:  28 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  Rad
 
Authors-red:  Plakas SM, James MO
 
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