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Title:
Effect of temperature and diet composition on residue depletion of oxytretracycline in cultured channel catfish.
Authors:
Luzzana U, Serrini G, Moretti VM, Maggi GL, Valfre F, Polidori P
Drug:
Oxytetracycline
Fish species:
Catfish, channel
Date:
1994
Sample:
muscle
Ave Weight (gm):
945
Ave Water temp (°C):
23
Water:
Freshwater
Dosage:
7500 mg/kg 7d
Route:
PO
Comments:
Three diet compositions tested (control diet = CD, high energy high protein = HEP, high energy high lipid=HEL) at two different water temperatures (18C, 23C). Oxytetracycline residue concentration (ug/kg) CD at 23C: 1d post-dose=98.4, 3d post-dose=38.6, 8d post-dose=19.5, 13d post-dose=not detected (nd), 18d post-dose=nd. Oxytetracycline residue concentration (ug/kg) HEP at 23C: 1d post-dose=79.6, 3d post-dose=37.3, 8d post-dose=12.1, 13d post-dose=nd, 18d post-dose=nd. Oxytetracycline residue concentration (ug/kg) HEL at 23C: 1d post-dose=81.5, 3d post-dose=50.8, 8d post-dose=12.1, 13d post-dose=nd, 18d post-dose=nd. Effects of diet on oxytetracycline absorption, metabolism and excretion in channel catfish are significant at 18C and no statistically significant differences found at 23C.
Citation:
Analyst 119:2757-2759
Link:
http://www.ncbi.nlm.nih.gov/pubmed/7879890
Genus Species:
Ictalurus punctatus
Drug Class:
Antibiotic-Tetracycline
Wt gm-detail:
945+/- 173g
Water temp (°C)-detail:
23C (Range: 23.1-23.3C)
Dosage-detail:
7500 mg/kg 7d
Method:
HPLC
Authors-red:
Luzzana U, Serrini G, Moretti VM, Maggi GL, Valfre F, Polidori P
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