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U.S. Department of Health and Human Services

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Title:  Long depletion time of enrofloxacin in rainbow trout (Oncorhynchus mykiss).
 
Authors:  Lucchetti D, Fabrizi L, Guandalini E, Podesta E, Marvasi L, Zaghini A, Coni E
 
Drug:  Enrofloxacin
 
Fish species:  Trout, rainbow
 
Date:  2004
 
t1/2-hr:  168
 
est:  est
 
Sample:  muscle+skin
 
Ave Weight (gm):  250
 
Ave Water temp (°C):  13
 
Water:  Freshwater
 
Dosage:  10 mg/kg 5 d
 
Route:  PO
 
Comments:  Average Residue d0.5=0.56, d1=0.78, d2=0.68, d4=0.57, d7=0.18, d10=0.08, d20=LOD, d30=LOD, d40=LOD, d48=LOD, d60=LOD mg/kg. Cage study in a river. T 1/2 est from table.
 
Metabolites:  ciprofloxacin
 
Citation:  Antimicrobial Agents and Chemotherapy 48:3912-3917
 
Dep-time:  LOD at 265 deg day (approx 27 d at 10 deg C)
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15388452  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  7 day est at 12-13 deg
 
Wt gm-detail:  250 g
 
Water temp (°C)-detail:  13.25 C days 1-20, 12 C day 21+
 
Dosage-detail:  10 mg/kg 5d
 
Method:  HPLC
 
Authors-red:  Lucchetti D, Fabrizi L, Guandalini E, Podesta E, Marvasi L, Zaghini A, Coni E
 
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