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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics and bioavailability of flumequine and oxolinic acid after various routes of administration to Atlantic salmon in seawater.
 
Authors:  Rogstad A, Ellingsen OF, Syvertsen C
 
Drug:  Flumequine
 
Fish species:  Salmon, Atlantic
 
Date:  1993
 
t1/2-hr:  23
 
Sample:  blood, plasma
 
Ave Weight (gm):  425
 
Ave Water temp (°C):  5
 
Water:  Saltwater
 
Dosage:  4.9 mg/kg sd
 
Route:  IV
 
Comments:  Salinity 30ppt. Residues 0.5h=4.9, 1h=3.8, 2h=2.8, 4h=1.6, 6h=1.1, 8h=0.9,12h=0.8, 24h=0.5, 48h=0.3, 72h=0.2, 96h=0.2 ug/ml. AUC=46.5 ug h/ml. T 1/2 alpha 1.3h
 
Cl:  0.095 L/kg/h
 
Vc:  0.8 L/kg
 
Vd:  3.1 L/kg
 
Citation:  Aquaculture 110:207-220
 
Link:  http://www.sciencedirect.com/science/article/pii/004484869390369A  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  23+/-5 h
 
Wt gm-detail:  425 g
 
Water temp (°C)-detail:  5+/-0.2 C
 
Dosage-detail:  4.9 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Rogstad A, Ellingsen OF, Syvertsen C
 
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