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U.S. Department of Health and Human Services

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Title:  Temperature-dependent absorption and elimination of flumequine in rainbow trout (Oncorhynchus mykiss Walbaum) in fresh water.
 
Authors:  Sohlberg S, Aulie A, Soli NE
 
Drug:  Flumequine
 
Fish species:  Trout, rainbow
 
Date:  1994
 
t1/2-hr:  137
 
Sample:  blood, plasma
 
Ave Weight (gm):  498
 
Ave Water temp (°C):  13
 
Water:  Freshwater
 
Dosage:  5 mg/kg sd
 
Route:  IVC
 
Comments:  Catheterized fish. Residues 2h=3.7, 4h=3.1, 8h=2.5, 12h=2.1, 24h=1.6, 36h=1.2, 48h=0.97, 73h= 0.9, 96h=0.8, 168h=0.7, 268h=0.5, 412h=0.6, 745h=0.2, 1070h=0.16, 1465h=0.11 (controls at 13C could have value of 0.13-0.22.) ug/ml. t1/2 alpha=2.9h, beta10.3, gamma137h.
 
Cl:  0.018 L/kg/h
 
Vd:  3.2 L/kg
 
Citation:  Aquaculture 119:1-10
 
Link:  http://dx.doi.org/10.1016/0044-8486(94)90439-1  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  t1/2 alpha=2.9h, beta10.3, gamma137h.
 
Wt gm-detail:  499+/-133 g
 
Water temp (°C)-detail:  13+/-1 C
 
Dosage-detail:  5 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Sohlberg S, Aulie A, Soli NE
 
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