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U.S. Department of Health and Human Services

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Title:  Dosage regime experiments with oxolinic acid and flumequine in Atlantic salmon (Salmo salar L) held in sea water.
 
Authors:  Ellingsen OF, Midttun B, Rogstad A, Syversten C, Samuelsen OB
 
Drug:  Oxolinic acid
 
Fish species:  Salmon, Atlantic
 
Date:  2002
 
Sample:  liver
 
Ave Weight (gm):  2000
 
Ave Water temp (°C):  20
 
Water:  Saltwater
 
Dosage:  158 mg/kg on d 1,2,4,6
 
Route:  PO
 
Comments:  Dosing done on farm with outbreak of furnculosis. Fed Apoxolon Akvaletter Vet 5 g/kg. Good distribution in plasma, muscle and liver with concentration in the 1.7-29.2 ug/ml range. Flumequine conc were 2-9 times higher than oxolinic acid.
 
Citation:  Aquaculture 209:19-34
 
Link:  http://dx.doi.org/10.1016/S0044-8486(01)00804-3  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
Wt gm-detail:  2000 g
 
Water temp (°C)-detail:  17-22 C
 
Dosage-detail:  158 mg/kg fish fed d 1,2,4,6
 
Method:  HPLC
 
Authors-red:  Ellingsen OF, Midttun B, Rogstad A, Syversten C, Samuelsen OB
 
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