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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics and tissue distribution of oxytetracycline in sea bass, Dicentrarchus labrax, at two water temperatures.
 
Authors:  Rigos G, Alexis M, Andriopoulou, A, Nengas I
 
Drug:  Oxytetracycline
 
Fish species:  Seabass, European
 
Date:  2002
 
t1/2-hr:  10
 
Sample:  blood, plasma
 
Ave Weight (gm):  110
 
Ave Water temp (°C):  22
 
Water:  Saltwater
 
Dosage:  40 mg/kg sd
 
Route:  IV
 
Comments:  alpha t 1/2 0.192 h. AUC 529.35 ug/h/ml. Residue 1 h= 38.6, 8h= 13.5, 128 h= 0.6 ug/g.
 
Cl:  0.0687 L/kg/h
 
Vc:  0.060 L/kg
 
Vd:  2.59 L/kg
 
Citation:  Aquaculture 210:59-67
 
Link:  http://dx.doi.org/10.1016/S0044-8486(01)00868-7  Opens a new window
 
Genus Species:  Dicentrarchus labrax
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  9.65 h
 
Wt gm-detail:  110 g
 
Water temp (°C)-detail:  22+/-1 C
 
Dosage-detail:  40 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Rigos G, Alexis M, Andriopoulou, A, Nengas I
 
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