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U.S. Department of Health and Human Services

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Title:  Tissue distribution and residue depletion of oxolinic acid in gilthead seabream (Sparus aurata) and sharpsnout sea bream (Diplodus puntazzo) following multiple in-feed dosings.
 
Authors:  Rigos G, Nengas I, Alexis M, Tyrpenou AE, Troisi GM
 
Drug:  Oxolinic acid
 
Fish species:  Seabream, sharpsnout
 
Date:  2004
 
t1/2-hr:  19
 
Sample:  blood, plasma
 
Ave Weight (gm):  120
 
Ave Water temp (°C):  19
 
Water:  Saltwater
 
Dosage:  30 mg/kg 10 d
 
Route:  PO
 
Comments:  Displayed biphasic elimination in tissues and reached "consumer safe levels 24 h after treatment. Residues ng/ml = d1=260, d2=270, d3=330, d4=460, d5=910, d6=320, d7=370, d8=340, d9=160, d10=140, d11=60, d12=30, d14=20, d15=20, d17=20. AUC=97 ug/h ml.
 
Citation:  Aquaculture 224:245-256
 
Link:  http://dx.doi.org/10.1016/S0044-8486(03)00213-8   Opens a new window
 
Genus Species:  Diplodus puntazzo
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  19 h
 
Wt gm-detail:  120+/-20 g
 
Water temp (°C)-detail:  19 +/-1 C
 
Dosage-detail:  30 mg/kg for 10 d
 
Method:  HPLC
 
Authors-red:  Rigos G, Nengas I, Alexis M, Tyrpenou AE, Troisi GM
 
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