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U.S. Department of Health and Human Services

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Title:  Attempt to validate breakpoint MIC values estimated from pharmacokinetic data obtained during oxolinic acid therapy of winter ulcer disease in Atlantic salmon (Salmo salar).
 
Authors:  Coyne R, Bergh O, Samuelsen O, Andersen K, Lunestad BT, Nilsen H, Dalsgaard I, Smith P
 
Drug:  Oxolinic acid
 
Fish species:  Salmon, Atlantic-dead
 
Date:  2004
 
Sample:  muscle
 
Ave Weight (gm):  225
 
Ave Water temp (°C):  7
 
Water:  Saltwater
 
Dosage:  175 mg/kg sd*
 
Route:  PO
 
Comments:  DEAD fish. Dosing administered on commercial marine farm over 13d with outbreak of winter ulcer disease. Oxolinic acid administered in feed pellets. Fish fed medicated feed on days 15, 16, 19, 21, 23, 25, and 27 and normal feed on other days. Quantifiable residue found in 1 of 10 dead fish at 28d, 24hr post feeding.
 
Citation:  Aquaculture 238:51-66
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2004.04.027  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
Wt gm-detail:  200-250 gm
 
Water temp (°C)-detail:  5.2-7.2 C
 
Dosage-detail:  175 mg/kg fish fed d 15,16,19,21,23,25,27*
 
Method:  HPLC
 
Authors-red:  Coyne R, Bergh O, Samuelsen O, Andersen K, Lunestad BT, Nilsen H, Dalsgaard I, Smith P
 
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