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Title:
Attempt to validate breakpoint MIC values estimated from pharmacokinetic data obtained during oxolinic acid therapy of winter ulcer disease in Atlantic salmon (Salmo salar).
Authors:
Coyne R, Bergh O, Samuelsen O, Andersen K, Lunestad BT, Nilsen H, Dalsgaard I, Smith P
Drug:
Oxolinic acid
Fish species:
Salmon, Atlantic-healthy
Date:
2004
Sample:
blood, plasma
Ave Weight (gm):
225
Ave Water temp (°C):
7
Water:
Saltwater
Dosage:
175 mg/kg sd*
Route:
PO
Comments:
HEALTHY fish. Dosing administered on commercial marine farm over 13d with outbreak of winter ulcer disease. Oxolinic acid administered in feed pellets. Fish fed medicated feed on days 15, 16, 19, 21, 23, 25, and 27 and normal feed on other days. Quantifiable residue found in 1 of 10 dead fish at 28d, 24hr post feeding.
Citation:
Aquaculture 238:51-66
Link:
http://dx.doi.org/10.1016/j.aquaculture.2004.04.027
Genus Species:
Salmo salar
Drug Class:
Antibiotic-Quinolone
Wt gm-detail:
200-250 gm
Water temp (°C)-detail:
5.2-7.2 C
Dosage-detail:
175 mg/kg fish fed d 15,16,19,21,23,25,27*
Method:
HPLC
Authors-red:
Coyne R, Bergh O, Samuelsen O, Andersen K, Lunestad BT, Nilsen H, Dalsgaard I, Smith P
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