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U.S. Department of Health and Human Services

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Title:  A comparison of oxolinic acid concentrations in farmed and laboratory held rainbow trout (Oncorhynchus mykiss) following oral therapy.
 
Authors:  Coyne R, Samuelsen O, Kongshaug H, Andersen K, Dalsgaard I, Smith P, Bergh O.
 
Drug:  Oxolinic acid
 
Fish species:  Trout, rainbow
 
Date:  2004
 
Sample:  blood, plasma
 
Ave Weight (gm):  248
 
Ave Water temp (°C):  12
 
Water:  Saltwater
 
Dosage:  50mg/kg 6 d*
 
Route:  PO
 
Comments:  Farm fish Moribund: Medicated feed 5g/kg fed at 1% body wt on days 1,2,3,5,7,9. Study compared healthy laboratory fish with farm fish during an outbreak of Vibrio. Residues, mg/l, 24 hr p feeding Lab fish=0.133 (<0.005-0.266) 80th %=0.09, Heathy farm=0.156 (<0.005-0.602) 80%=0.05, Not statistically different. 22 of 29 moribund and 6 of 10 dead fish had no essentially residues, and were not feeding..
 
Citation:  Aquaculture 239:1-13
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2003.11.034  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
Wt gm-detail:  248+/-60 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  Medicated feed 50mg/kg for 6 d*
 
Method:  HPLC
 
Authors-red:  Coyne R, Samuelsen O, Kongshaug H, Andersen K, Dalsgaard I, Smith P, Bergh O.
 
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