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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  On the validity of setting breakpoint minimum inhibition concentrations at one quarter of plasma concentration achieved following oral administration of oxytetracycline.
 
Authors:  Coyne R, Samuelsen O, Bergh O, Andersen K, Pursell L, Dalsgaard I, Smith P
 
Drug:  Oxytetracycline
 
Fish species:  Salmon, Atlantic-healthy
 
Date:  2004
 
Sample:  blood, plasma
 
Ave Weight (gm):  10
 
Ave Water temp (°C):  13
 
Water:  Freshwater
 
Dosage:  75 mg/kg 10 d
 
Route:  PO
 
Comments:  Mean serum OTC conc mg/L on day 1 after 10 day treatment =0.25 [0.25 median]. 26 fish.
 
Citation:  Aquaculture 239:23-35
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2004.05.036  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Tetracycline
 
Wt gm-detail:  10 g
 
Water temp (°C)-detail:  13.3 C
 
Dosage-detail:  75 mg/kg 10 d
 
Method:  HPLC
 
Authors-red:  Coyne R, Samuelsen O, Bergh O, Andersen K, Pursell L, Dalsgaard I, Smith P
 
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