Quick Links: Skip to main page content Skip to Search Skip to Topics Menu Skip to Common Links
  • Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

PhishPharm - Detail
  • Print
  • Share
  • E-mail
-
 
Title:  The biopharmaceutics and oral bioavailability of two forms of oxytetracycline to the white shrimp, Litopenaeus setiferus.
 
Authors:  Reed LA, Siewicki TC, Shah JC
 
Drug:  Oxytetracycline
 
Fish species:  Shrimp, northern white
 
Date:  2006
 
t1/2-hr:  18
 
est:  est
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  23
 
Ave Water temp (°C):  21
 
Water:  Saltwater
 
Dosage:  100 mg/kg 1 d
 
Route:  PO
 
Comments:  Tested OTC monoalkyl trimethyl quaternary salt formulation. 2x less soluble than dihydrate form. Salinity=20ppt. Tmax=19.2+/-6.6 h. Cmax=19.2+/-7.5 ug/mL. AUC=739+/-299 ug h/mL. F=49.5+/-19.7%. Vd=Vc+Vp. Dep-time est 4d from curve. t1/2-hr extrapolated from curve. Bioavai.=50%
 
Vc:  715 mL/kg
 
Vd:  2310 mL/kg
 
Citation:  Aquaculture 258:42-54
 
Dep-time:  4 d
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2006.03.029  Opens a new window
 
Genus Species:  Litopenaeus setiferus
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  alpha= 5 h est beta= 18 h est
 
Wt gm-detail:  14.92-31.44g
 
Water temp (°C)-detail:  20+/-2 C
 
Dosage-detail:  100 mg/kg 1 d
 
Method:  HPLC
 
Authors-red:  Reed LA, Siewicki TC, Shah JC
 
-
-