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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Pharmacokinetics of eugenol in rainbow trout (Oncorhynchus mykiss).
 
Authors:  Guenette SA, Uhland FC, Helie P, Beaudry F, Vachon P
 
Drug:  Eugenol
 
Fish species:  Trout, rainbow
 
Date:  2007
 
t1/2-hr:  12
 
Sample:  blood
 
Ave Weight (gm):  64
 
Ave Water temp (°C):  4
 
Water:  Freshwater
 
Dosage:  75 mg/L for 15 min
 
Route:  BATH
 
Comments:  Liver, kidneys, heart, and gills were collected for histopathology, with no tissue anomalies revealed. Biphasic curve suggestive of enterohepatic circulation. Cmax = 10.53 ug/mL, AUCt = 16.55 ug h/mL, AUCinf = 17.04 ug h/mL. Used MS222 to take repeated blood samples. Estimated concentrations from graph: 1h=8.0 ug/ml, 2h=2.0, 5h=0.5, 10h=0.4, 20h=0.1 ug/ml.
 
Citation:  Aquaculture 266:262-265
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2007.02.046  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Anesthetic-Methoxyphenol
 
t1/2-detail:  12.14 h
 
Wt gm-detail:  63.7 +/- 14.4 g
 
Water temp (°C)-detail:  4 C
 
Dosage-detail:  75 mg/L for 15 min
 
Method:  LC, MS
 
Authors-red:  Guenette SA, Uhland FC, Helie P, Beaudry F, Vachon P
 
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