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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in Scylla serrata following oral gavage at two salinities.
 
Authors:  Fang WH, Zhou S, Yu HJ, Hu LL, Zhou K, Liang SC
 
Drug:  Enrofloxacin
 
Fish species:  Crab, mud
 
Date:  2007
 
t1/2-hr:  73
 
Sample:  muscle
 
Ave Weight (gm):  140
 
Ave Water temp (°C):  25
 
Water:  Freshwater
 
Dosage:  30 mg/kg sd
 
Route:  PO
 
Comments:  VALUES FOR PARENT. Cmax in muscle was 18.62 ug/g two hours after oral gavage. Salinity 4 ppt, AUC=1183.5 ug/h/g.
 
Cl:  0.025
 
Vd:  2.667
 
Metabolites:  Ciprofloxacin
 
Citation:  Aquaculture 272:180-187
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2007.08.049  Opens a new window
 
Genus Species:  Scylla serrata
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  72.88
 
Wt gm-detail:  120-160 g
 
Water temp (°C)-detail:  25 +/- 1 C
 
Dosage-detail:  Single dose of 0.5 ml/kg at 60 g/L corresponding to 30mg/kg
 
Method:  HPLC
 
Authors-red:  Fang WH, Zhou S, Yu HJ, Hu LL, Zhou K, Liang SC
 
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