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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in Scylla serrata following oral gavage at two salinities.
Authors:  Fang, WH, Zhou, S, Yu, HJ, Hu, LL, Zhou, K, Liang, SC
Drug:  Enrofloxacin
Fish species:  Crab, mud
Date:  2007
t1/2-hr:  73
Sample:  muscle
Ave Weight (gm):  140
Ave Water temp (°C):  25
Water:  Freshwater
Dosage:  30 mg/kg sd
Route:  PO
Comments:  Cmax in muscle was 18.62 ug/g two hours after oral gavage. Salinity 4 ppt, AUC=1183.5 ug/h/g.
Cl:  0.025
Vd:  2.667
Metabolites:  Ciprofloxacin
Citation:  Aquaculture 272:180-187
Link:  http://dx.doi.org/10.1016/j.aquaculture.2007.08.049  Opens a new window
Genus Species:  Scylla serrata
Drug Class:  Antibiotic-Quinolone
t1/2-detail:  72.88
Wt gm-detail:  120-160 g
Water temp (°C)-detail:  25 +/- 1 C
Dosage-detail:  Single dose of 0.5 ml/kg at 60 g/L corresponding to 30mg/kg
Method:  HPLC
Authors-red:  Fang, WH, Zhou, S, Yu, HJ, Hu, LL, Zhou, K, Liang, SC