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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Pharmacokinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in Scylla serrata following oral gavage at two salinities.
Authors:  Fang WH, Zhou S, Yu HJ, Hu LL, Zhou K, Liang SC
Drug:  Enrofloxacin
Fish species:  Crab, mud
Date:  2007
t1/2-hr:  77
Sample:  hepatopancreas
Ave Weight (gm):  140
Ave Water temp (°C):  25
Water:  Freshwater
Dosage:  30 mg/kg sd
Route:  PO
Comments:  VALUES FOR CIPRO - Salinity 4 ppt. Cmax 2.55 at 96 h. AUC 425 ug/g.h.
Cl:  0.071
Vd:  7.8
Metabolites:  Ciprofloxacin
Citation:  Aquaculture 272:180-187
Link:  http://dx.doi.org/10.1016/j.aquaculture.2007.08.049  Opens a new window
Genus Species:  Scylla serrata
Drug Class:  Antibiotic-Quinolone
t1/2-detail:  76.49
Wt gm-detail:  120-160 g
Water temp (°C)-detail:  25 +/- 1 C
Dosage-detail:  Single dose of 0.5 ml/kg at 60 g/L corresponding to 30mg/kg
Method:  HPLC
Authors-red:  Fang WH, Zhou S, Yu HJ, Hu LL, Zhou K, Liang SC