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U.S. Department of Health and Human Services

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Title:  Residue depletion of tritium-labeled Ivermectin in rainbow trout following oral administraiton.
 
Authors:  Shaikh B, Rummel N, Gieseker C, Chu PS, Reimschuessel R
 
Drug:  Ivermectin
 
Fish species:  Trout, rainbow
 
Date:  2007
 
t1/2-hr:  576
 
Sample:  muscle
 
Ave Weight (gm):  843
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  0.1 mg/kg sd
 
Route:  PO
 
Comments:  Ivermectin [3H]. Half life of the parent ivermectin was 312 h and parent plus major metabolite combined was 528 h.Max TRR = 71 ng/g d3, declined to 16 on d42. By day 35 65% of TRR was the metabolite. Radioactivity d1=21, d3=53, d7=43, d14=29, d28=22, d35=12, d42=10 ng/g.
 
Metabolites:  3" -O-demethyl-H2B1a
 
Citation:  Aquaculture 272:192-198
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2007.08.050  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antiparasitic-Avermectin
 
t1/2-detail:  13 d parent, 22 d metabolite, 24 d Total
 
Wt gm-detail:  500-1500 g
 
Water temp (°C)-detail:  12+/- 2 C
 
Dosage-detail:  Single dose 0.1 mg/kg tritium-labeled ivermectin in a gel capsule via stomach tube
 
Method:  LC, HPLC-Rad
 
Authors-red:  Shaikh B, Rummel N, Gieseker C, Chu PS, Reimschuessel R
 
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