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U.S. Department of Health and Human Services

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Title:  Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O.caureus) after a single oral administration in freshwater and seawater at 28 C.
Authors:  Feng JB, Jia XP, Li LD.
Drug:  Florfenicol
Fish species:  Tilapia (hybrid)
Date:  2008
t1/2-hr:  8
Sample:  Muscle
Ave Weight (gm):  115
Ave Water temp (°C):  28
Water:  Freshwater
Dosage:  10 mg/Kg sd
Route:  PO
Comments:  Cmax = 4.59ug/g Tmax=12 hrs ; 1.6ug/g after 24hrs. During later sampling times (12-168 h) concentrations of florfenicol were ususally higher in freshwater tilapia than in seawater. Florfenicol residues, estimated from graph: 2h= 1.5 ug/g, 4h= 1.5 ug/g, 6h= 0.5 ug/g, 8h= 2.5, 10h= 1, 12h=5, 18h= 2, 24h= 2, 48h= <0.25.
Metabolites:  Florfenicol amine
Citation:  Aquaculture 276:29-35
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.01.002  Opens a new window
Genus Species:  Oreochromis niloticus x O. aureus
Drug Class:  Antibiotic-Phenicol
t1/2-detail:  8.03hr
Wt gm-detail:  115 g
Water temp (°C)-detail:  28 +/- 1 C
Dosage-detail:  10 mg/kg sd
Method:  HPLC
Authors-red:  Feng JB, Jia XP, Li LD.