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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics, plasma cortisol and effectiveness of benzocaine, MS-222 and isoeugenol measured in individual dorsal aorta-cannulated Atlantic Salmon (Salmo salar) following bath administration
 
Authors:  Kiessling A, Johansson D, Zahl IH, Samuelsen OB
 
Drug:  MS-222
 
Fish species:  Salmon, Atlantic
 
Date:  2009
 
t1/2-hr:  0
 
Sample:  blood, plasma
 
Ave Weight (gm):  1600
 
Ave Water temp (°C):  9
 
Water:  Saltwater
 
Dosage:  65 mg/l
 
Route:  BATH
 
Comments:  Gill ventilation after exposure. Fish were sedated with metomidate hydro3chloride (0.25 mg/l) for dorsal aorta cannulation and anaesthetized with MS-222 (60 mg/l). Cmax=14.7 ug/ml. MRT=1.2 min. Plasma cortisol peaked at 30 min at 588 ng/ml. Ventilation following exposure exposure greatly increased elimination rate. Anaesthetics were administered in two steps; an initial ten minute, low dose sedation, followed by a full strength anaesthesia bath.
 
Cl:  3.54 l/kg/h
 
Vc:  4.39 l/kg
 
Citation:  Aquaculture 286: 301-308
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.09.037  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Anesthetic-Tricaine
 
t1/2-detail:  1.3 min
 
Wt gm-detail:  1600+/-250
 
Water temp (°C)-detail:  9+/-1.5
 
Method:  HPLC
 
Authors-red:  Kiessling A, Johansson D, Zahl IH, Samuelsen OB
 
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