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U.S. Department of Health and Human Services

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Title:  Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 C.
 
Authors:  Feng JB, Jia XP
 
Drug:  Florfenicol
 
Fish species:  Tilapia (hybrid)
 
Date:  2009
 
t1/2-hr:  14
 
Sample:  liver
 
Ave Weight (gm):  98
 
Ave Water temp (°C):  22
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  PO
 
Comments:  Tmax reached at 12 h. Cmax concentration = 5.87 ug g. Drug elimination was rapid, declining to 0.07 ug g at 168 h. Tissue:plasma ratio: 2h=2.8, 4h=2.7, 6h=2.0, 8h=2.0, 10h=1.3, 12h=1.3, 18h=1.2, 24h=1.4, 48h=1.0, 72h=1.4, 96h=1.0, 168h=1.6. Range = 0.98-2.80.
 
Citation:  Aquaculture 289: 129-133
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.12.023  Opens a new window
 
Genus Species:  Oreochromis niloticus x O. aureus
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  13.94 h
 
Wt gm-detail:  98g
 
Water temp (°C)-detail:  22 +/- 1 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Feng JB, Jia XP
 
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