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U.S. Department of Health and Human Services

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Title:  Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 C.
 
Authors:  Feng JB, Jia XP
 
Drug:  Florfenicol
 
Fish species:  Tilapia (hybrid)
 
Date:  2009
 
t1/2-hr:  17
 
Sample:  kidney
 
Ave Weight (gm):  98
 
Ave Water temp (°C):  22
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  PO
 
Comments:  Tmax reached at 12 h. Cmax concentration = 6.89 ug g. Elimination was relatively slow, declining to 0.16 ug g at 168 h. Tissue:Plasma ratio: 2h=1.7, 4h=2.0, 6h=2.5, 8h=2.0, 10h=1.7, 12h=1.6, 18h=1.9, 24h=2.4, 48h=2.3, 72h=3.5, 96h=2.4, 168h = 3.7. Range = 1.55-3.74.
 
Citation:  Aquaculture 289: 129-133
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.12.023  Opens a new window
 
Genus Species:  Oreochromis niloticus x O. aureus
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  16.62 h
 
Wt gm-detail:  98g
 
Water temp (°C)-detail:  22 +/- 1 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Feng JB, Jia XP
 
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