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U.S. Department of Health and Human Services

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Title:  Pharmacokinetic disposition of enrofloxacin in brown trout (Salmo trutta fario) after oral and intravenous administrations
 
Authors:  Koc F, Uney K, Atamanalp M, Tumer I, Kaban G
 
Drug:  Enrofloxacin
 
Fish species:  Trout, brown
 
Date:  2009
 
t1/2-hr:  19
 
Sample:  blood, plasma
 
Ave Weight (gm):  170
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  IV
 
Comments:  Fish were anestitised with 30 mgL MS-222. Ciprofloxacin was not detected in plasma at any of the time points, 0.08-120h following administration. Half life alpha=0.88. AUC=70.1.
 
Cl:  0.14 L kg h
 
Vd:  3.40 L kg
 
Metabolites:  Ciprofloxacin
 
Citation:  Aquaculture 295: 142-144
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2009.06.004  Opens a new window
 
Genus Species:  Salmo trutta fario
 
Drug Class:  Antibiotic - Quinolone
 
t1/2-detail:  19.14+/-1.51
 
Wt gm-detail:  170+/-32
 
Water temp (°C)-detail:  10
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC-UV
 
Authors-red:  Koc F, Uney K, Atamanalp M, Tumer I, Kaban G
 
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