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U.S. Department of Health and Human Services

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Title:  Disappearance of malachite green residues in fry of rainbow trout (Onchorhynchus mykiss) after treatment of eggs at the hatching stage
 
Authors:  Niska K, Korkea-aho T, Lindfors E, Kiuru T, Tuomainen M, Taskinen J, Peltonen K
 
Drug:  Malachite Green
 
Fish species:  Trout, rainbow
 
Date:  2009
 
Sample:  whole body
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  3 mg/L 30 min
 
Route:  BATH
 
Comments:  Eggs were exposed to malachite green (MG) at 7 days post fertilization (dpf) for 30 minutes. Exposure was continued twice a week on 10, 14, 17, 21, and 25 dpf. Leucomalachite green (LMG) was the major residue found in fry indicating that malachite green (MG) can penetrate through the eggshell into the embryo and be metabolized. In newly hatched fry MG concentration was about 276 ug/kg and LMG concentration was about 1170 ug/kg. 16 days post hatch (dph) MG concentration was about 1.8 ug/kg and LMG concentration was about 70.9 ug/kg. 31 dph MG concentration was below 1 ug/kg and LMG concentration was about 2.7 ug/kg. 43 dph no MG or LMG residues above the limit of detection were found.
 
Metabolites:  Leucomalachite green
 
Citation:  Aquaculture 297: 25-30
 
Link:  http://www.sciencedirect.com/science/article/pii/S0044848609007480  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic - Dye
 
Water temp (°C)-detail:  12.3+/-1.2 (10.5-13.9)
 
Dosage-detail:  3 mg/L
 
Method:  LC-MS/MS
 
Authors-red:  Niska K, Korkea-aho T, Lindfors E, Kiuru T, Tuomainen M, Taskinen J, Peltonen K
 
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