Quick Links: Skip to main page content
Skip to Search
Skip to Topics Menu
Skip to Common Links
U.S. Food & Drug Administration
Follow FDA
En Español
Search FDA
Home
Food
Drugs
Medical Devices
Radiation-Emitting Products
Vaccines, Blood & Biologics
Animal & Veterinary
Cosmetics
Tobacco Products
PhishPharm - Detail
FDA Home
PhishPharm
Detail
-
Please note:
JavaScript must be enabled for this application to work properly.
Check your settings
if you are unsure if your JavaScript is enabled.
Title:
Distribution and elimination of oxolinic acid in rainbow trout (Oncorhynchus mykiss Walbaum) after single rapid intravascular injection.
Authors:
Hustvedt SO, Salte R
Drug:
Oxolinic acid
Fish species:
Trout, rainbow
Date:
1991
t1/2-hr:
29
Sample:
blood, serum
Ave Weight (gm):
1180
Ave Water temp (°C):
9
Water:
Saltwater
Dosage:
10 mg/kg sd
Route:
IVC
Comments:
Mean serum conc ug/ml 15 min=18.5, 45 min=9.8, 90 min=6.4., 3h=3.3, 6h=3.4, 9h=2.7, 12h=2.4, 24h=1.4, 48h=0.7, 96h=0.34, 144h=0.14, 192h=0.05. Cannulated fish. Saltwater 25 ppt. AUC=200 ug*h/ml. T 1/2 alpha=0.2, beta=2.4, gamma=29.1 h.
Cl:
0.083 L/kg/h
Vd:
2.6 L/kg
Citation:
Aquaculture 92:297-303
Link:
http://dx.doi.org/10.1016/0044-8486(91)90035-6
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
alpha=0.2, beta=2.4, gamma=29.1 h, range 19.5-42.8 h gamma
Wt gm-detail:
1180 +/-110 g
Water temp (°C)-detail:
8.5+/-0.5 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC/RP, HPLC
Authors-red:
Hustvedt SO, Salte R
-
-