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U.S. Department of Health and Human Services

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Title:  Absorption, distribution and elimination of oxolinic acid in Atlantic salmon (Salmo salar L.) after various routes of administration.
 
Authors:  Hustvedt SO, Salte R, Vassvik V
 
Drug:  Oxolinic acid
 
Fish species:  Salmon, Atlantic
 
Date:  1991
 
t1/2-hr:  60
 
Sample:  blood, serum
 
Ave Weight (gm):  575
 
Ave Water temp (°C):  9
 
Water:  Saltwater
 
Dosage:  20 mg/kg sd
 
Route:  IV
 
Comments:  Fish were cannulated and given an asprin PO after the surgery, then acclimated 3 weeks. AUC=782 ug/h ml. Cmax 69.6 ug/ml at 0 h. T 1/2 alpha 0.3, beta=5.1, gamma=60.3h.
 
Cl:  0.029 L/kg/h
 
Vd:  1.8 L/kg
 
Citation:  Aquaculture 95:193-199
 
Link:  http://dx.doi.org/10.1016/0044-8486(91)90086-M  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  alpha 0.3, beta=5.1, gamma=60.3h, gamma range= 50.5-77.8 h
 
Wt gm-detail:  575+/-110 g
 
Water temp (°C)-detail:  9+/-0.5 C
 
Dosage-detail:  20 mg/kg sd
 
Method:  HPLC/RP, HPLC
 
Authors-red:  Hustvedt SO, Salte R, Vassvik V
 
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